MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

@article{Helvoort1996MDR1PI,
  title={MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine},
  author={Ardy van Helvoort and Alexander D. Smith and Hein Sprong and Ingo Fritzsche and Alfred H Schinkel and Piet Borst and Gerrit van Meer},
  journal={Cell},
  year={1996},
  volume={87},
  pages={507-517}
}
The human MDR1 P-glycoprotein (Pgp) extrudes a variety of drugs across the plasma membrane. The homologous MDR3 Pgp is required for phosphatidylcholine secretion into bile. After stable transfection of epithelial LLC-PK1 cells, MDR1 and MDR3 Pgp were localized in the apical membrane. At 15 degrees C, newly synthesized short-chain analogs of various membrane lipids were recovered in the apical albumin-containing medium of MDR1 cells but not control cells. MDR inhibitors and energy depletion… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 252 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Absenceof the mdr1a P-glycoprotein inmice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A

  • A. H. Schinkel, E. Wagenaar, L. van Deemter, Mol, C.A.A.M, P. Borst
  • J. Clin. Invest
  • 1995
Highly Influential
5 Excerpts

The mouse multidrug resistance C8C8-PA

  • P. Gros, E. Buschman
  • 1993
Highly Influential
4 Excerpts

on the basolateral surface of epithelial (Madin-Darby canine

  • T. Pomorski, P. Müller, B. Zimmermann, K. Burger, P. F. Devaux
  • Transbilayer movement of fluorescent and J. Biol…
  • 1996
2 Excerpts

C6-NBD-[3H]PC, fluorescence and autoradiography

  • G.A, T. M. McIntyre, S. M. Prescott
  • 1995

Similar Papers

Loading similar papers…