MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case–control studies

@article{Sheng2012MDR1CP,
  title={MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case–control studies},
  author={Xiaojing Sheng and Limei Zhang and Na Tong and Dewei Luo and Meilin Wang and Min Xu and Zhengdong Zhang},
  journal={Molecular Biology Reports},
  year={2012},
  volume={39},
  pages={7237-7249}
}
Multidrug resistance 1 (MDR1) gene encodes the ATP-dependent cellular efflux pump P-glycoprotein (P-gp) which efflux of a variety of substances across the membrane. P-gp could serve a role in cancer etiology based on its physiological role of protecting cells from xenobiotics or metabolites. The C3435T (rs1045642) polymorphism of the MDR1 gene which could influence the P-gp expression and function have been implicated in the cancer risk. However, the results from the published studies on the… CONTINUE READING
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