MDR1 (ABCB1) polymorphisms: functional effects and clinical implications.

  title={MDR1 (ABCB1) polymorphisms: functional effects and clinical implications.},
  author={Aniel Jessica-Leticia Brambila-Tapia},
  journal={Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion},
  volume={65 5},
MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three single nucleotide polymorphisms (SNPs) in the coding region (C3435T, C1236T and G2677T/A) are the most widely studied SNPs in MDR1 and have been related to substrate and inhibitor-dependent functional modifications in in vitro studies and reduced expression in tissues. The three SNPs exhibit the highest frequencies in Asian… CONTINUE READING


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