MDR-related P170-glycoprotein modulates cytotoxic activity of homoharringtonine.

  title={MDR-related P170-glycoprotein modulates cytotoxic activity of homoharringtonine.},
  author={Domenico Russo and Angela Michelutti and C M Melli and Daniela Damiani and Maria Grazia Michieli and Anna Candoni and D. K. Zhou and Jean Paul Marie and Robert Zittoun and Michele Baccarani},
  volume={9 3},
Homoharringtonine (HHT) is a new drug with antileukemic activity which is currently tested for treatment of acute and chronic leukemias, either alone or in combination with other agents. Since HHT showed a low efficacy in refractory and relapsed acute leukemia and in the blastic phase of chronic myeloid leukemia (CML) which are frequently characterized by an overexpresion of the multidrug resistance (MDR)-related P170-glycoprotein, we postulated a relationship between the poor antileukemic… CONTINUE READING