MDR quinone oxidoreductases: the human and yeast zeta-crystallins.

  title={MDR quinone oxidoreductases: the human and yeast zeta-crystallins.},
  author={Sergio Port{\'e} and Eva Crosas and Evgenia A. Yakovtseva and Josep Antoni Biosca and Jaume Farr{\'e}s and Maria Rosario Fern{\'a}ndez and Xavier Par{\'e}s},
  journal={Chemico-biological interactions},
  volume={178 1-3},
The medium-chain dehydrogenase/reductase (MDR) superfamily can be divided into Zn-containing and Zn-lacking proteins. Zn-containing MDRs are generally well-known enzymes, mostly acting as dehydrogenases. The non-Zn MDR are much less studied, and classified in several families of NADP(H)-dependent reductases, including quinone oxidoreductases (QOR). zeta-Crystallins are the best studied group of QOR, have a structural function in the lens of several mammals, exhibit ortho-quinone reductase… CONTINUE READING


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