MDR- and CYP3A4-Mediated Drug–Drug Interactions

  title={MDR- and CYP3A4-Mediated Drug–Drug Interactions},
  author={Dhananjay Pal and Ashim K Mitra},
  journal={Journal of Neuroimmune Pharmacology},
P-glycoprotein (P-gp), multiple drug resistance associated proteins (MRPs), and cytochrome P450 3A4 together constitute a highly efficient barrier for many orally absorbed drugs. Multidrug regimens and corresponding drug–drug interactions are known to cause many adverse drug reactions and treatment failures. Available literature, clinical reports, and in vitro studies from our laboratory indicate that many drugs are substrates for both P-gp and CYP3A4. Our primary hypothesis is that transport… CONTINUE READING
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