MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells

@article{Chen2000MDR1A,
  title={MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells},
  author={Gong Chen and George E. Dur{\'a}n and Alexandra Mangili and Lidija Beketi{\'c}-Ore{\vs}kovi{\'c} and Branimir Sikic},
  journal={British Journal of Cancer},
  year={2000},
  volume={83},
  pages={892 - 898}
}
Single-step selection with vinblastine was performed in populations of the human sarcoma cell line MES-SA, to assess cellular mechanisms of resistance to the drug and mutation rates via fluctuation analysis. At a stringent selection with 20 nM vinblastine, resulting in 5–6 logs of cell killing, the mutation rate was 7 × 10–7per cell generation. Analysis of variance supported the hypothesis of spontaneous mutations conferring vinblastine resistance, rather than induction of adaptive response… CONTINUE READING
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Prevalence multidrug resistance related to activation of the mdr 1 gene in human sarc mutants derived by single - step doxorubicin selection

  • G Chen, Jaffrézou J-P, WH Fleming, GE Durán, BI Sikic
  • Cancer Res
  • 1994
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