MDMB-CHMICA induces thrashing behavior, bradycardia, and slow pressor response in a CB1- and CB2-receptor-dependent manner in conscious rats

@article{Maeda2018MDMBCHMICAIT,
  title={MDMB-CHMICA induces thrashing behavior, bradycardia, and slow pressor response in a CB1- and CB2-receptor-dependent manner in conscious rats},
  author={Hideyuki Maeda and Erika Nagashima and Yukiko K. Hayashi and Ruri Kikura-Hanajiri and Ken-ichi Yoshida},
  journal={Forensic Toxicology},
  year={2018},
  volume={36},
  pages={313-319}
}
PurposeMDMB-CHMICA, a new synthetic cannabinoid (SC), has become prevalent since 2014 as an ingredient of recreational drugs. Reports on intoxication due to the drug have been increasing, which show diverse cardiovascular, psychiatric, and neuronal symptoms. Reports on sudden death and accidental death related to psychiatric disorders in MDMB-CHMICA intoxication have also increased, but the underlying mechanisms are largely unknown.MethodsAs there has been no experimental study on the drug, we… 
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