MDMB-CHMICA induces thrashing behavior, bradycardia, and slow pressor response in a CB1- and CB2-receptor-dependent manner in conscious rats

@article{Maeda2018MDMBCHMICAIT,
  title={MDMB-CHMICA induces thrashing behavior, bradycardia, and slow pressor response in a CB1- and CB2-receptor-dependent manner in conscious rats},
  author={Hideyuki Maeda and Erika Nagashima and Yukiko K. Hayashi and Ruri Kikura-Hanajiri and Ken-ichi Yoshida},
  journal={Forensic Toxicology},
  year={2018},
  volume={36},
  pages={313-319}
}
PurposeMDMB-CHMICA, a new synthetic cannabinoid (SC), has become prevalent since 2014 as an ingredient of recreational drugs. Reports on intoxication due to the drug have been increasing, which show diverse cardiovascular, psychiatric, and neuronal symptoms. Reports on sudden death and accidental death related to psychiatric disorders in MDMB-CHMICA intoxication have also increased, but the underlying mechanisms are largely unknown.MethodsAs there has been no experimental study on the drug, we… 
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4 Citations

The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogues
TLDR
5F-PYPICA and 5F-Y-PINACA did not produce cannabimimetic effects in mice at doses up to 10 mg/kg, and analogues intended to explore structure-activity relationships within this class of SCRAs were synthesized and characterized.
Analyzing cannabinoid-induced abnormal behavior in a zebrafish model
TLDR
The behavioral effects of marijuana depend on the ratio of the two different cannabinoid properties, and the repeated light and dark test might be a suitable method for drug-induced behavioral assay.
The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogs.
TLDR
Five SCRA NPS evaluated in vivo using radio biotelemetry did not produce cannabimimetic effects in mice at doses up to 10 mg/kg and expansion of the pyrrolidine ring of 5F-PY-PICA to an azepane conferred the greatest hCB2 affinity and activity within the series.
The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution.
TLDR
This chapter will chart the evolution of recently identified SCRA NPS chemotypes, as well as their putative manufacturing by-products and thermolytic degradants, and describe structure-activity relationships within each class.

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