MDMB-CHMICA induces thrashing behavior, bradycardia, and slow pressor response in a CB1- and CB2-receptor-dependent manner in conscious rats

@article{Maeda2018MDMBCHMICAIT,
  title={MDMB-CHMICA induces thrashing behavior, bradycardia, and slow pressor response in a CB1- and CB2-receptor-dependent manner in conscious rats},
  author={Hideyuki Maeda and Erika Nagashima and Yukiko K. Hayashi and Ruri Kikura-Hanajiri and Ken-ichi Yoshida},
  journal={Forensic Toxicology},
  year={2018},
  volume={36},
  pages={313-319}
}
PurposeMDMB-CHMICA, a new synthetic cannabinoid (SC), has become prevalent since 2014 as an ingredient of recreational drugs. Reports on intoxication due to the drug have been increasing, which show diverse cardiovascular, psychiatric, and neuronal symptoms. Reports on sudden death and accidental death related to psychiatric disorders in MDMB-CHMICA intoxication have also increased, but the underlying mechanisms are largely unknown.MethodsAs there has been no experimental study on the drug, we… 
View on Springer
5 Citations
Methods Citations
1

5 Citations

The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogues
TLDR
5F-PYPICA and 5F-Y-PINACA did not produce cannabimimetic effects in mice at doses up to 10 mg/kg, and analogues intended to explore structure-activity relationships within this class of SCRAs were synthesized and characterized.
Analyzing cannabinoid-induced abnormal behavior in a zebrafish model
TLDR
The behavioral effects of marijuana depend on the ratio of the two different cannabinoid properties, and the repeated light and dark test might be a suitable method for drug-induced behavioral assay.
The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogs.
TLDR
Five SCRA NPS evaluated in vivo using radio biotelemetry did not produce cannabimimetic effects in mice at doses up to 10 mg/kg and expansion of the pyrrolidine ring of 5F-PY-PICA to an azepane conferred the greatest hCB2 affinity and activity within the series.
The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution.
TLDR
This chapter will chart the evolution of recently identified SCRA NPS chemotypes, as well as their putative manufacturing by-products and thermolytic degradants, and describe structure-activity relationships within each class.
Analyzing cannabinoid-induced abnormal behavior in a zebrafish model
  • PloS one
  • 2020

References

SHOWING 1-10 OF 20 REFERENCES
Δ9-Tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons
Cannabinoids cause central sympathoexcitation and bradycardia in rabbits.
TLDR
The results indicate that cannabinoids, acting directly on cardiovascular regulatory centers, elicit sympathoactivation and bradycardia.
Behavioral effects of the novel cannabinoid full agonist AM 411
The complexities of the cardiovascular actions of cannabinoids
TLDR
The cardiovascular actions of cannbinoids are complex and in conscious animals, the picture is one of bradycardia followed by pressor responses, but clearly the responses to cannabinoids are dependent on the experimental conditions and synthetic cannabinoids and endocannabinoids exhibit different pharmacologies.
Effect of the cannabinoid receptor agonist WIN55212‐2 on sympathetic cardiovascular regulation
TLDR
The results obtained in pithed rabbits indicate that activation of CB1 cannabinoid receptors leads to marked peripheral prejunctional inhibition of noradrenaline release from postganglionic sympathetic axons.
Cannabinoids Acting on CB1 Receptors Decrease Contractile Performance in Human Atrial Muscle
TLDR
The conclusion is that anandamide, R-methanandamide and HU-210 decrease contractile performance in human atrial muscle via CB1 receptors.
The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression
TLDR
Results show that activation of CB1 cannabinoid receptors induces sympathoinhibition and enhancement of cardiac vagal tone, leading to hypotension and bradycardia, and the cannabinoid-evoked cardiovascular depression depends strongly on the respiratory state of the animals.
Clinical toxicity following analytically confirmed use of the synthetic cannabinoid receptor agonist MDMB-CHMICA. A report from the Identification Of Novel psychoActive substances (IONA) study
TLDR
Analytically confirmed exposure to MDMB-CHMICA was associated with acidosis, reduced level of consciousness, mydriasis, heart rate disturbances and convulsions, and recovery occurred within 24 h in all cases except one male also exposed to methiopropamine.
Regional haemodynamic responses to the cannabinoid agonist, WIN 55212‐2, in conscious, normotensive rats, and in hypertensive, transgenic rats
TLDR
The results indicate that the predominant cardiovascular effects of WIN 55212‐2 in conscious HSD and TG rats can be attributed largely to indirect, pentolinium‐sensitive mechanisms, which appear to differ little in the normotensive and hypertensive state, at least in conscious animals.
Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues.
TLDR
In vitro and in vivo data indicate that these SCs act as highly efficacious CB receptor agonists with greater potency than Δ(9)-THC and earlier generations of SCs.
...
...