MDMA induces caspase-3 activation in the limbic system but not in striatum.

@article{Tamburini2006MDMAIC,
  title={MDMA induces caspase-3 activation in the limbic system but not in striatum.},
  author={Ilaria Tamburini and Fabio Blandini and Marco Gesi and Giada Frenzilli and Marco Nigro and Mario Giusiani and Antonio Paparelli and Francesco Fornai},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1074},
  pages={
          377-81
        }
}
Several studies, carried out in chronic (+/-) 3,4-methylenedioxymethamphetamine (MDMA) abusers, have shown memory loss and cognitive impairment, as well as persistent electroencephalographic changes. This suggests that, at least in humans, forebrain areas, including the limbic system, might be altered by MDMA. Consistently, recent experimental evidences suggest that, in rodents, MDMA, besides effects on the basal ganglia, produces alterations in the hippocampus. Therefore, the aim of the… CONTINUE READING

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