MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate.

@article{Huff2016MDMADG,
  title={MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate.},
  author={Courtney Huff and Rachel L. Morano and James P Herman and Bryan K. Yamamoto and Gary A. Gudelsky},
  journal={Neurotoxicology},
  year={2016},
  volume={57},
  pages={
          282-290
        }
}
  • Courtney Huff, Rachel L. Morano, +2 authors Gary A. Gudelsky
  • Published in Neurotoxicology 2016
  • Biology, Medicine, Chemistry
  • 3,4-Methylenedioxy-methamphetamine (MDMA) is a unique psychostimulant that continues to be a popular drug of abuse. It has been well documented that MDMA reduces markers of 5-HT axon terminals in rodents, as well as humans. A loss of parvalbumin-immunoreactive (IR) interneurons in the hippocampus following MDMA treatment has only been documented recently. In the present study, we tested the hypothesis that MDMA reduces glutamic acid decarboxylase (GAD) 67-IR, another biochemical marker of GABA… CONTINUE READING

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