MDMA-assisted therapy: A new treatment model for social anxiety in autistic adults

  title={MDMA-assisted therapy: A new treatment model for social anxiety in autistic adults},
  author={Alicia Danforth and Christopher M. Struble and Berra Yazar-Klosinski and Charles S. Grob},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},

Figures and Tables from this paper

MDMA – hopes and fears associated with therapeutic use in mental disorders

It seems that further studies are needed to determine the long-term safety and effectiveness of MDMA assisted psychotherapy, as data available in the literature suggest that psychoactive substances may be safely administered in clinical settings.

Social Work and Psychedelic-Assisted Therapies: Practice Considerations for Breakthrough Treatments

The re-emergence of therapeutic uses for mind-altering, psychedelic drugs has brought the field of mental health to a new frontier in research, practice, and policymaking. In the past two decades

Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study

This pilot trial demonstrated rapid and durable improvement in social anxiety symptoms in autistic adults following MDMA-assisted psychotherapy, which supports expansion of research into larger samples to further investigate this novel treatment for social anxiety.

Legalizing MDMA-Assisted Psychotherapy for the Treatment of Trauma-Related Mental Health Disorders

Considering the limitations of existing treatments for trauma-related disorders, MDMA’s pharmacological and psychological effects, and the growing body of methodologically sound research on MDMA-assisted psychotherapy, legalizing this type of therapy could provide much-needed relief to people struggling with the severe, painful, lifelong effects of trauma and related psychological disorders.

Psychedelic-Assisted Therapy for Social Adaptability in Autistic Adults.

  • A. Danforth
  • Psychology, Medicine
    Current topics in behavioral neurosciences
  • 2021
The purpose of this chapter will be to inform researchers and clinicians on the history of clinical research with classic psychedelics with autistic minors, recent and current clinical trials of atypical psychedelICS with autistic adults, and considerations for providing psychedelic-assisted psychotherapies that are compatible with autism.

Current Perspective on MDMA-Assisted Psychotherapy for Posttraumatic Stress Disorder

Empirical support for MDMA-assisted psychotherapy, including the randomized, double-blind, placebo-controlled trails that have been conducted since 2008, seems to support MDMA’s safe and effective use as an adjunct to psychotherapy.

MDMA-Assisted Psychotherapy for Posttraumatic Stress Disorder: Implications for Social Work Practice and Research

The pervasive impact of trauma across populations and stages of life has made it imperative that the field of social work remain at the forefront of trauma-informed theory, research, and practice.

BReduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study^

Rationale Standard therapeutic approaches to reduce social anxiety in autistic adults have limited effectiveness. Since 3,4methylenedioxymethamphetamine (MDMA)-assisted psychotherapy shows promise as

Methylenedioxymethamphetamine (MDMA) in Psychiatry: Pros, Cons, and Suggestions

The proposed potential of MDMA as an adjunct to psychotherapy for PTSD is evaluated and suggestions of alternative treatments based on the behavioral pharmacology and toxicology of MDMA and its enantiomers are presented.

MDMA for the Treatment of Negative Symptoms in Schizophrenia

This review provides a rationale for the use of MDMA in the treatment of negative symptoms by reviewing the literature on negative symptoms, their treatment, MDMA, and MDMA-assisted therapy and concludes with considerations regarding safety and possible mechanisms of action.



A Clinical Plan for MDMA (Ecstasy) in the Treatment of Posttraumatic Stress Disorder (PTSD): Partnering with the FDA

  • R. Doblin
  • Psychology
    Journal of psychoactive drugs
  • 2002
Abstract The FDA and the Spanish Ministry of Health have concluded that the risk/benefit ratio is favorable under certain circumstances for clinical studies investigating MDMA-assisted psychotherapy.

How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale

MDMA has a combination of pharmacological effects that, in a therapeutic setting, could provide a balance of activating emotions while feeling safe and in control, as described in case reports of MDMA-augmented psychotherapy.

The Potential Dangers of Using MDMA for Psychotherapy

  • A. Parrott
  • Psychology
    Journal of psychoactive drugs
  • 2014
Abstract MDMA has properties that may make it attractive for psychotherapy, although many of its effects are potentially problematic. These contrasting effects will be critically reviewed in order to

MDMA-Assisted Psychotherapy Using Low Doses in a Small Sample of Women with Chronic Posttraumatic Stress Disorder

It was found that low doses of MDMA were both psychologically and physiologically safe for all the subjects and future studies in larger samples and using larger doses are needed in order to further clarify the safety and efficacy of MDMA in the clinical setting in subjects with PTSD.

A method of conducting therapeutic sessions with MDMA.

The therapists' belief was that MDMA inhibited the fear response to a perceived emotional threat, allowing the client to place the emotional sequelae of past experiences into a more realistic perspective in their current emotional lives and relationships.

A randomized, controlled pilot study of MDMA (±3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD)

This randomized, double-blind, active-placebo controlled trial found that MDMA-assisted psychotherapy can be safely administered in a clinical setting and did not see statistically significant reductions in CAPS scores, although there was clinically and statistically significant self-reported PDS improvement.

The safety and efficacy of ±3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study

MDMA-assisted psychotherapy can be administered to posttraumatic stress disorder patients without evidence of harm, and it may be useful in patients refractory to other treatments.

Courage, connection, and clarity: A mixed-methods collective-case study of MDMA (ecstasy) experiences of autistic adults

The purpose of this mixed-methods study was to explore how autistic adults experience the subjective effects of the drug 3,4-methylenedioxymethamphetamine (MDMA), which is also known as the street