MDMA-Induced Dissociative State not Mediated by the 5-HT2A Receptor

@inproceedings{Puxty2017MDMAInducedDS,
  title={MDMA-Induced Dissociative State not Mediated by the 5-HT2A Receptor},
  author={Drew J. Puxty and Johannes Gerardus Ramaekers and Rafael de la Torre and Mag{\'i} Farr{\'e} and Neus Pizarro and Mitona Pujadas and Kim P C Kuypers},
  booktitle={Front. Pharmacol.},
  year={2017}
}
Previous research has shown that a single dose of MDMA induce a dissociative state, by elevating feelings of depersonalization and derealization. Typically, it is assumed that action on the 5-HT2A receptor is the mechanism underlying these psychedelic experiences. In addition, other studies have shown associations between dissociative states and biological parameters (heart rate, cortisol), which are elevated by MDMA. In order to investigate the role of the 5-HT2 receptor in the MDMA-induced… CONTINUE READING

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