MDMA (ecstasy) pharmacokinetics in a CYP2D6 poor metaboliser and in nine CYP2D6 extensive metabolisers

Abstract

MDMA (3,4-methylenedioxymethamphetamine, ecstasy) is a ring-substituted amphetamine widely abused by the youth for its euphoric and empathic effects. MDMA’s metabolic disposition includes as its first step an O-demethylenation to 3,4-dihydroxymethamphetamine (HHMA), regulated by cytochrome P450 (CYP) isoform 2D6 [2]. HHMA is further metabolised to 4hydroxy… (More)
DOI: 10.1007/s00228-005-0965-y

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Cite this paper

@article{Torre2005MDMAP, title={MDMA (ecstasy) pharmacokinetics in a CYP2D6 poor metaboliser and in nine CYP2D6 extensive metabolisers}, author={Rafael de la Torre and Mag{\'i} Farr{\'e} and Brian {\'O} Math{\'u}na and Pere Nolasc Roset and Neus Pizarro and Mireia Segura and Marta Torrens and Jordi Ortu{\~n}o and Mitona Pujadas and Jordi Cam{\'i}}, journal={European Journal of Clinical Pharmacology}, year={2005}, volume={61}, pages={551-554} }