MDMA 'ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI.

@article{Rouine2013MDMAI,
  title={MDMA 'ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI.},
  author={Jennifer Rouine and Oliviero L Gobbo and Melissa Campbell and Valentina Gigliucci and Ian. Ogden and K McHugh Smith and Paul E. Duffy and Brendan Behan and Dean Byrne and Melanie E. M. Kelly and Christoph W. Blau and Christian M. Kerskens and Andrew Harkin},
  journal={British journal of pharmacology},
  year={2013},
  volume={169 5},
  pages={
          974-87
        }
}
  • Jennifer Rouine, Oliviero L Gobbo, +10 authors Andrew Harkin
  • Published in
    British journal of…
    2013
  • Medicine, Chemistry
  • BACKGROUND AND PURPOSE The purpose of this study was to assess cerebral perfusion changes following systemic administration of the recreational drug 3,4-methylendioxymethamphetamine (MDMA 'ecstasy') to rats. EXPERIMENTAL APPROACH Cerebral perfusion was quantified using bolus-tracking arterial spin labelling (btASL) MRI. Rats received MDMA (20 mg·kg(-1); i.p.) and were assessed 1, 3 or 24 h later. Rats received MDMA (5 or 20 mg·kg(-1); i.p.) and were assessed 3 h later. In addition, rats… CONTINUE READING

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