MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.

@article{Meehan1995MDMAS,
  title={MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.},
  author={Susan Meehan and T L Gordon and Martin D. Schechter},
  journal={Alcohol},
  year={1995},
  volume={12 6},
  pages={569-72}
}
Selectively bred high- and low-alcohol-drinking (HAD/LAD) rats were trained to discriminate the interoceptive stimuli produced by IP-administered 600 mg/kg ethanol (10% w/v in a two-lever, food-motivated operant task. Once criterion discrimination was attained, animals were tested with 3.0, 1.5, 1.0, and 0.5 mg/kg MDMA. Although no differences in alcohol discrimination were observed between the HAD and LAD animals, the HAD line was significantly more sensitive than the LAD line to the effects… CONTINUE READING

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