MDM2SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk.


OBJECTIVES SNP309 polymorphism (T-G) at the promoter region of MDM2 has been reported to cause increased binding affinity of transcriptional activator Sp1 followed by increased MDM2 both in mRNA and protein level. This model was proposed in vitro in the small panel of cell lines that indicated an on average 8-fold higher level of MDM2 mRNA in cells bearing… (More)
DOI: 10.1159/000139135


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