MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes.

@article{Hayashida2013MDM2RA,
  title={MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes.},
  author={Kyoko Hayashida and Kiichi Kajino and Masakazu Hattori and Maura Wallace and Ivan Morrison and M ichael Greene and Chihiro Sugimoto},
  journal={Experimental and molecular pathology},
  year={2013},
  volume={94 1},
  pages={228-38}
}
Our efforts are concerned with identifying features of incomplete malignant transformation caused by non viral pathogens. Theileria parva (T. parva) is a tick-transmitted protozoan parasite that can cause a fatal lymphoproliferative disease in cattle. The T. parva-infected lymphocytes display a transformed phenotype and proliferate in culture media like the other tumor cells, however those cells will return to normal after antiprotozoal treatment reflecting the incomplete nature of… CONTINUE READING

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