MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis.

Abstract

Induction of apoptosis in tumor cells is an important mechanism of chemotherapy-induced cell death. The tumor-suppressor gene p53 is required for the efficient activation of apoptosis following chemotherapy. However, the molecular mechanism regulating p53-associated apoptosis remains controversial. In this study, we show that the expression of both wild… (More)

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@article{Kondo1995MDM2PC, title={MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis.}, author={S. Kondo and Gene H. Barnett and Hideaki Hara and Tatsuo Morimura and Junichiro Takeuchi}, journal={Oncogene}, year={1995}, volume={10 10}, pages={2001-6} }