MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis.

@article{Ohmiya2006MDM2PP,
  title={MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis.},
  author={Naoki Ohmiya and Ayumu Taguchi and Nobuyuki Mabuchi and Akihiro Itoh and Yoshiki Hirooka and Yasumasa Niwa and Hidemi Goto},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 27},
  pages={4434-40}
}
PURPOSE Recently, a single-nucleotide polymorphism in the MDM2 promoter (SNP309) has been found to lower the age of onset of tumors and increase the occurrence of multiple primary tumors in Li-Fraumeni syndrome, and accelerate the development of sporadic adult soft tissue sarcoma. The aim of this study was to determine whether SNP309 is associated with susceptibility to gastric carcinoma and its prognosis. PATIENTS AND METHODS In a case-control study including 438 controls and 410 patients… CONTINUE READING
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