MDM2 controls the timely expression of cyclin A to regulate the cell cycle.

  title={MDM2 controls the timely expression of cyclin A to regulate the cell cycle.},
  author={Rebecca A. Frum and Mahesh Ramamoorthy and Lathika Mohanraj and Sumitra Deb and Swati Palit Deb},
  journal={Molecular cancer research : MCR},
  volume={7 8},
Overexpression of MDM2 has been related to oncogenesis. In this communication, we present evidence to show that MDM2 controls the cell cycle-dependent expression of cyclin A by using a pathway that ensures its timely expression. MDM2 does not inhibit cyclin D or E expression. Silencing of endogenous MDM2 expression elevates cyclin A expression. The p53-binding domain of MDM2 harbors a SWIB region homologous to a conserved domain of a chromosome remodeling factor BRG1-associated protein. The… CONTINUE READING
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The human oncoprotein MDM2 arrests the Frum et al. Mol Cancer Res 2009;7(8)

  • DR Brown, CA Thomas, SP. Deb
  • August 2009 1266 on June
  • 2009
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