MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy.

@article{Kojima2005MDM2AI,
  title={MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy.},
  author={Kensuke Kojima and Marina Konopleva and Ismael J. Samudio and Masato Shikami and Maria da Graça Cabreira-Hansen and Teresa S. McQueen and Vivian R Ruvolo and Twee Tsao and Zhihong Zeng and Lyubomir T. Vassilev and Michael Andreeff},
  journal={Blood},
  year={2005},
  volume={106 9},
  pages={3150-9}
}
Although TP53 mutations are rare in acute myeloid leukemia (AML), inactivation of wild-type p53 protein frequently occurs through overexpression of its negative regulator MDM2 (murine double minute 2). Recently, small-molecule antagonists of MDM2, Nutlins, have been developed that inhibit the p53-MDM2 interaction and activate p53 signaling. Here, we study the effects of p53 activation by Nutlin-3 in AML cells. Treatment with MDM2 inhibitor triggered several molecular events consistent with… CONTINUE READING
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