MDM2 and MDMX bind and stabilize the p53-related protein p73

@article{Ongkeko1999MDM2AM,
  title={MDM2 and MDMX bind and stabilize the p53-related protein p73},
  author={W. Ongkeko and X. Q. Wang and W. Y. Siu and A. Lau and K. Yamashita and A. Harris and L. Cox and R. Poon},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={829-832}
}
The p53 gene encodes one of the most important tumor suppressors in human cells and undergoes frequent mutational inactivation in cancers. MDM2, a transcriptional target of p53, binds p53 and can both inhibit p53-mediated transcription [1] [2] and target p53 for proteasome-mediated proteolysis [3] [4]. A close relative of p53, p73, has recently been identified [5] [6]. Here, we report that, like p53, p73alpha and the alternative transcription product p73beta also bind MDM2. Interaction between… Expand
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  • XiaoQi Wang, Talha Arooz, +4 authors R. Poon
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