MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation.

@article{Galli2010MDM2AF,
  title={MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation.},
  author={Francesco Galli and Mariangela Rossi and Yuri D'Alessandra and Marco De Simone and Teresa Lopardo and Ygal Haupt and Osnat Alsheich-Bartok and Shira Anzi and Eitan Shaulian and Viola Calabr{\`o} and Girolama La Mantia and Luisa Guerrini},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 14},
  pages={2423-33}
}
Tight control of p63 protein levels must be achieved under differentiation or apoptotic conditions. Here, we describe a new regulatory pathway for the DeltaNp63alpha protein. We found that MDM2 binds DeltaNp63alpha in the nucleus promoting its translocation to the cytoplasm. The MDM2 nuclear localization signal is required for DeltaNp63alpha nuclear export and subsequent degradation, whereas the MDM2 ring-finger domain is dispensable. Once exported to the cytoplasm by MDM2, p63 is targeted for… CONTINUE READING

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