MDM2 amplification and loss of heterozygosity at Rb and p53 genes: no simultaneous alterations in the oncogenesis of liposarcomas

@article{SchneiderStock1998MDM2AA,
  title={MDM2 amplification and loss of heterozygosity at Rb and p53 genes: no simultaneous alterations in the oncogenesis of liposarcomas},
  author={Regine Schneider-Stock and Hajo Walter and Kathrin Radig and Janusz Ryś and Alexander Bosse and Cornelius Kuhnen and Cuong Hoang-Vu and Albert Roessner},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={1998},
  volume={124},
  pages={532-540}
}
Purpose: The present study aimed to investigate the status of alterations of the MDM2, Rb and p53 genes in a series of 45 liposarcomas. Furthermore, the possible correlation with histological and clinical parameters was studied. Methods: MDM2 amplification was examined by non-radioactive Southern blot hybridization with a human MDM2 cDNA probe. Mutations in the p53 gene were screened by polymerase chain reaction/single-strand conformation polymorphism analysis and direct sequencing. To study… CONTINUE READING
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