MDM2 SNP309 promoter polymorphism, an independent prognostic factor in chronic lymphocytic leukemia.

BACKGROUND The single nucleotide polymorphism SNP309 with a change from T to G in the promoter region of the MDM2 gene is shown to increase the MDM2 protein levels and attenuate the p53 levels and associates with disease progression in several tumors. OBJECTIVE In this study, the role of the polymorphism was investigated with regard to the clinical… (More)