MDM2 SNP309 contributes to non-small cell lung cancer survival in Chinese.

@article{Dong2011MDM2SC,
  title={MDM2 SNP309 contributes to non-small cell lung cancer survival in Chinese.},
  author={Jing Dong and Binhui Ren and Zhibin Hu and Jiaping Chen and Lingmin Hu and Juncheng Dai and Guangfu Jin and Lin Xu and Hongbing Shen},
  journal={Molecular carcinogenesis},
  year={2011},
  volume={50 6},
  pages={
          433-8
        }
}
Murine double minute 2 (MDM2) is a negative regulator of the tumor suppressor gene p53. Single nucleotide polymorphisms in MDM2 and p53 can affect patient's response to chemotherapy as well as overall survival of many cancers. This study aimed to assess the associations between polymorphisms in MDM2 and p53 and survival of non-small cell lung cancer (NSCLC) patients in Chinese. We selected and genotyped both potentially functional SNPs and tagging SNPs in MDM2 and p53 using Illumina Golden Gate… CONTINUE READING
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Citations

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Role of MDM2 T309G polymorphism in susceptibility and prognosis of nonsmall cell lung cancer: a meta-analysis.

  • Genetic testing and molecular biomarkers
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