MDM2–MOF–H4K16ac axis contributes to tumorigenesis induced by Notch

@article{Liu2014MDM2MOFH4K16acAC,
  title={MDM2–MOF–H4K16ac axis contributes to tumorigenesis induced by Notch},
  author={Y. Liu and Zhao-bin Xing and Shu-qing Wang and Su Chen and Yan-kun Liu and Yu-Hui Li and Yu-Feng Li and Ya-qi Wang and Y. Lu and Wan-ning Hu and Jing-Hua Zhang},
  journal={The FEBS Journal},
  year={2014},
  volume={281}
}
Identification of the epigenetic mechanisms involved in the transmission of Notch signaling is useful for personalized medicine. We observed that aberrantly high levels of Notch activity resulted in H4K16ac downregulation in hepatocellular carcinoma and breast cancer cell lines and tissues. This downregulated acetylation was a consequence of increased male on the first degradation following the upregulation of full‐length murine double minute 2 in different cancer types. We observed that… Expand
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