MDC1 is ubiquitylated on its tandem BRCT domain and directly binds RAP80 in a UBC13-dependent manner.

@article{Strauss2011MDC1IU,
  title={MDC1 is ubiquitylated on its tandem BRCT domain and directly binds RAP80 in a UBC13-dependent manner.},
  author={Carmit Strauss and Tomer Halevy and Michal Macarov and Liron Argaman and Michal Goldberg},
  journal={DNA repair},
  year={2011},
  volume={10 8},
  pages={806-14}
}
The cellular response to DNA damage is essential for maintenance of genomic stability. MDC1 is a key member of the DNA damage response. It is an adaptor protein that binds and recruits proteins to sites of DNA damage, a crucial step for a proper response. MDC1 contains several protein-protein interacting modules, including a tandem BRCT domain that mediates various interactions involving MDC1. Here we demonstrate that MDC1 binds directly to RAP80, which is a DNA damage response protein that… CONTINUE READING