MDA5 and TLR3 Initiate Pro-Inflammatory Signaling Pathways Leading to Rhinovirus-Induced Airways Inflammation and Hyperresponsiveness

@inproceedings{Wang2011MDA5AT,
  title={MDA5 and TLR3 Initiate Pro-Inflammatory Signaling Pathways Leading to Rhinovirus-Induced Airways Inflammation and Hyperresponsiveness},
  author={Qiong Wang and D J Miller and Emily R. Bowman and Deepti R. Nagarkar and Dina Schneider and Ying Zhao and Marisa J. Linn and Adam M Goldsmith and J Kelley Bentley and Umadevi S Sajjan and Marc B Hershenson},
  booktitle={PLoS pathogens},
  year={2011}
}
Rhinovirus (RV), a single-stranded RNA picornavirus, is the most frequent cause of asthma exacerbations. We previously demonstrated in human bronchial epithelial cells that melanoma differentiation-associated gene (MDA)-5 and the adaptor protein for Toll-like receptor (TLR)-3 are each required for maximal RV1B-induced interferon (IFN) responses. However, in vivo, the overall airway response to viral infection likely represents a coordinated response integrating both antiviral and pro… CONTINUE READING
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