MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma.

  title={MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma.},
  author={Swadesh Kumar Das and Sujit K Bhutia and Belal M Azab and Timothy P Kegelman and Leyla Peachy and Prasanna K Santhekadur and Santanu Dasgupta and Rupesh Dash and Paul C Dent and Steven Grant and Luni Emdad and Maurizio Pellecchia and Devanand Sarkar and Paul B Fisher},
  journal={Cancer research},
  volume={73 2},
Melanoma differentiation-associated gene-9 (mda-9/syntenin) encodes an adapter scaffold protein whose expression correlates with and mediates melanoma progression and metastasis. Tumor angiogenesis represents an integral component of cancer metastasis prompting us to investigate a possible role of mda-9/syntenin in inducing angiogenesis. Genetic (gain-of-function and loss-of-function) and pharmacologic approaches were used to modify mda-9/syntenin expression in normal immortal melanocytes… CONTINUE READING