MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway

@article{Han2016MD2MA,
  title={MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway},
  author={Jibo Han and C. Zou and L. Mei and Y. Zhang and Y. Qian and Shengban You and Y. Pan and Zheng Xu and Bin Bai and Weijian Huang and G. Liang},
  journal={Basic Research in Cardiology},
  year={2016},
  volume={112},
  pages={1-15}
}
  • Jibo Han, C. Zou, +8 authors G. Liang
  • Published 2016
  • Medicine
  • Basic Research in Cardiology
  • Angiotensin II (Ang II) induces cardiac inflammation and remodeling. Emerging evidence indicates that Ang II may utilize the Toll-like receptor 4 (TLR4) signaling pathway in mediating pro-inflammatory and pro-fibrotic activities. However, the precise mechanism is poorly understood. Myeloid differentiation 2 (MD2), a molecule that physically binds to TLR4, confers lipopolysaccharide responsiveness and may also be involved in mediating the actions of Ang II. We hypothesize that MD2 plays an… CONTINUE READING
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