MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway

@article{Han2016MD2MA,
  title={MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway},
  author={Jibo Han and Chunpeng Zou and Liqin Mei and Yali Zhang and Yuanyuan Qian and Shengban You and Yong Pan and Zheng Xu and Bin Bai and Wei-jian Huang and Guang Liang},
  journal={Basic Research in Cardiology},
  year={2016},
  volume={112},
  pages={1-15}
}
Angiotensin II (Ang II) induces cardiac inflammation and remodeling. Emerging evidence indicates that Ang II may utilize the Toll-like receptor 4 (TLR4) signaling pathway in mediating pro-inflammatory and pro-fibrotic activities. However, the precise mechanism is poorly understood. Myeloid differentiation 2 (MD2), a molecule that physically binds to TLR4, confers lipopolysaccharide responsiveness and may also be involved in mediating the actions of Ang II. We hypothesize that MD2 plays an… CONTINUE READING

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is modulated by nuclear factor - kappaBin the paraventricular nucleus

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