MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.

@article{Meng2010MD2mediatedII,
  title={MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.},
  author={Jianmin Meng and Egil Lien and Douglas T Golenbock},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 12},
  pages={8695-702}
}
Lipopolysaccharide (LPS) activates innate immune responses through TLR4.MD-2. LPS binds to the MD-2 hydrophobic pocket and bridges the dimerization of two TLR4.MD-2 complexes to activate intracellular signaling. However, exactly how lipid A, the endotoxic moiety of LPS, activates myeloid lineage cells remains unknown. Lipid IV(A), a tetra-acylated lipid A precursor, has been used widely as a model for lipid A activation. For unknown reasons, lipid IV(A) activates proinflammatory responses in… CONTINUE READING
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