MD-2 , a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor

Abstract

Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens. The TLR4 gene has recently been shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS). TLR4 may be a long-sought receptor for LPS. However… (More)

6 Figures and Tables

Topics

  • Presentations referencing similar topics