MCP-1 protects mice in lethal endotoxemia.

  title={MCP-1 protects mice in lethal endotoxemia.},
  author={David A. Zisman and Steven L. Kunkel and Robert M. Strieter and Wan C. Tsai and Kathy A. Bucknell and Jodi M. Wilkowski and Theodore J Standiford},
  journal={The Journal of clinical investigation},
  volume={99 12},
The overzealous production of proinflammatory cytokines in sepsis can result in shock, multiorgan dysfunction, and even death. In this study, we assessed the role of monocyte chemoattractant protein-1 (MCP-1) as a mediator of sepsis in endotoxin-challenged mice. Intraperitoneal administration of LPS to CD-1 mice induced a substantial time-dependent increase in MCP-1 in plasma, lung, and liver. The passive immunization of mice with rabbit antimurine MCP-1 antiserum 2 h before endotoxin… CONTINUE READING

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