MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1.

@article{Viedt2002MCP1II,
  title={MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1.},
  author={Christiane Viedt and Ralph Dechend and Jianwei Fei and Gertrud Maria Haensch and Joerg Kreuzer and Stephan Reinhold Orth},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 6},
  pages={
          1534-47
        }
}
Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine synthesized by several cell types, e.g., inflammatory cells, such as monocytes, and resident renal cells, such as human tubular epithelial cells (TECs). Besides induction of monocyte recruitment, MCP-1 has been suggested to induce non-leukocytes to produce cytokines and adhesion molecules. Inflammation of the tubulointerstitium is a hallmark of many renal diseases and contributes to progression of renal failure; the purpose… CONTINUE READING

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