MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels.

  title={MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels.},
  author={Chiara Fenoglio and Daniela Galimberti and Carlo Lovati and Ilaria Guidi and Alberto Gatti and Sergio Fogliarino and Marco Tiriticco and C. Mariani and Gianluigi Forloni and Carla Pettenati and Pierluigi Baron and Giancarlo Conti and Nereo Bresolin and Elio Scarpini},
  journal={Neurobiology of aging},
  volume={25 9},
MCP-1 levels are increased in CSF of patients with Alzheimer's disease (AD) compared with controls, suggesting a role in the development of dementia. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position -2518 has been found, influencing the level of MCP-1 expression in response to an inflammatory stimulus. The distribution of the A-2518G SNP was determined in 269 AD patients and in 203 healthy age matched controls, showing no differences between the two groups. On the… CONTINUE READING

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