MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

Abstract

Cellular stresses trigger autophagy to remove damaged macromolecules and organelles. Lysosomes 'host' multiple stress-sensing mechanisms that trigger the coordinated biogenesis of autophagosomes and lysosomes. For example, transcription factor (TF)EB, which regulates autophagy and lysosome biogenesis, is activated following the inhibition of mTOR, a… (More)
DOI: 10.1038/ncomms12109

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