MCM8 Is an MCM2-7-Related Protein that Functions as a DNA Helicase during Replication Elongation and Not Initiation

@article{Maiorano2005MCM8IA,
  title={MCM8 Is an MCM2-7-Related Protein that Functions as a DNA Helicase during Replication Elongation and Not Initiation},
  author={Domenico Maiorano and Olivier Cuvier and Etienne Danis and Marcel M{\'e}chali},
  journal={Cell},
  year={2005},
  volume={120},
  pages={315-328}
}
MCM2-7 proteins are replication factors required to initiate DNA synthesis and are currently the best candidates for replicative helicases. We show that the MCM2-7-related protein MCM8 is required to efficiently replicate chromosomal DNA in Xenopus egg extracts. MCM8 does not associate with the soluble MCM2-7 complex and binds chromatin upon initiation of DNA synthesis. MCM8 depletion does not affect replication licensing or MCM3 loading but slows down DNA synthesis and reduces chromatin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Identification of human cancer - related genes by naturally occurring Hepatitis B Virus DNA tagging

  • D. Gozuacik, M. Chami, +7 authors P. Paterlini-Brechot
  • Oncogene
  • 2003
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…