MCM2 is a therapeutic target of lovastatin in human non-small cell lung carcinomas.

@article{Zhang2015MCM2IA,
  title={MCM2 is a therapeutic target of lovastatin in human non-small cell lung carcinomas.},
  author={Xu Zhang and Yang Teng and Fang Yang and Meng Wang and Xuan Hong and Lei-Guang Ye and Yi-Na Gao and Gong-yan Chen},
  journal={Oncology reports},
  year={2015},
  volume={33 5},
  pages={2599-605}
}
Human non-small cell lung carcinoma (NSCLC) is one of the most common cancer worldwide. In previous studies, lovastatin, acting as an inhibitor of 3-hydroxy-3-methylglutaryl Co A (HMG-CoA) reductase, exhibited significant antitumor activity during tumorigenesis. However, whether or not this effect is mediated through changes in minichromosome maintenance (MCM) 2 expression remains unclear. The present study investigated whether lovastatin inhibits proliferation due to MCM2 in NSCLCs. We first… CONTINUE READING

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