MCM10 overexpression implicates adverse prognosis in urothelial carcinoma

  title={MCM10 overexpression implicates adverse prognosis in urothelial carcinoma},
  author={Wei-ming Li and C N Huang and H X Ke and C. C. Li and Yu-Ching Wei and Hsin-Chih Yeh and L C Chang and C. -F. Huang and P Q Liang and Bi-Wen Yeh and T. Chan and C. Li and W. J. Wu},
Urothelial carcinoma (UC) occurs in the upper urinary tract (UTUC) and the urinary bladder (UBUC). The molecular pathogenesis of UC has not been fully elucidated. Through data mining of a published transcriptome of UBUC (GSE31684), we identified Minichromosome Maintenance Complex Component 2 (MCM2) and MCM10 as the two most significantly upregulated genes in UC progression among the MCM gene family, the key factors for the initiation of DNA replication. To validate the clinical significance of… CONTINUE READING
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