MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis

@article{Craig2002MCL1PA,
  title={MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis},
  author={R. Bruce Craig},
  journal={Leukemia},
  year={2002},
  volume={16},
  pages={444-454}
}
The MCL1 gene (myeloid cell leukemia-1) was discovered serendipitously about a decade ago and proved to be a member of the emerging BCL2 gene family. Ongoing studies of this gene provide an interesting perspective on the role of the BCL2 family in transitions in cell phenotype. Specifically, gene products that influence cell viability as a major effect (eg MCL1, BCL2 and other family members) can act as key determinants in cell proliferation, differentiation and tumorigenesis. Although they do… CONTINUE READING
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Leukemia Exon skipping in Mcl1 results in a Bcl - 2 homology domain 3 ( BH 3 )only gene product that promotes cell death

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