MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

@article{Kozopas1993MCL1AG,
  title={MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.},
  author={Karen M Kozopas and Tao Yang and H L Buchan and Pengcheng Zhou and Ruth W. Craig},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 8},
  pages={3516-20}
}
During their lifespan, immature cells normally pass through sequential transitions to a differentiated state and eventually undergo cell death. This progression is aberrant in cancer, although the transition to differentiation can be reestablished in inducible leukemia cell lines. This report describes a gene, MCL1, that we isolated from the ML-1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Our results demonstrate that… CONTINUE READING
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