MCL0042: a nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity.

@article{Chaki2005MCL0042AN,
  title={MCL0042: a nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity.},
  author={Shigeyuki Chaki and Yuichi Oshida and Shin-ichi Ogawa and Takeo Funakoshi and Toshiharu Shimazaki and Taketoshi Okubo and Atsuro Nakazato and Shigeru Okuyama},
  journal={Pharmacology, biochemistry, and behavior},
  year={2005},
  volume={82 4},
  pages={621-6}
}
In the present study, we examined the anxiolytic and antidepressant effects of MCL0042, a novel compound showing activity in both MC4 receptor antagonism and serotonin transporter inhibition. MCL0042 showed relatively high affinity for the MC4 receptor and serotonin reuptake site, as determined by receptor binding assays. MCL0042 attenuated [Nle(4),d-Phe(7)]alpha-MSH-increased cAMP formation in MC4 receptor expressing cells, and it inhibited [(3)H]serotonin uptake by rat brain synaptosomes… CONTINUE READING

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