Corpus ID: 38850498

MCL-1 S , a Splicing Variant of the Antiapoptotic BCL-2 Family Member MCL-1 , Encodes a Proapoptotic Protein Possessing Only the BH 3 Domain *

  title={MCL-1 S , a Splicing Variant of the Antiapoptotic BCL-2 Family Member MCL-1 , Encodes a Proapoptotic Protein Possessing Only the BH 3 Domain *},
  author={Jeehyeon Bae and Chandra P. Leo and Sheau Yu Teddy Hsu and Aaron Jw Hsueh},
MCL-1 (myeloid cell leukemia-1) is an antiapoptotic BCL-2 family protein discovered as an early induction gene during myeloblastic leukemia cell differentiation. This survival protein has the BCL-2 homology (BH) domains 1, 2, and 3 and a C-terminal transmembrane region. We identified a short splicing variant of the MCL-1 mRNA in the human placenta encoding a protein, termed MCL-1 short (MCL-1S), with an altered C terminus as compared with the full-length MCL-1 long (MCL1L), leading to the loss… Expand

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Splicing Variant of MCL-1 Induces Apoptosis 25261 by gest on Sptem er 14
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