MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET.

@article{Mosconi2004MCICT,
  title={MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET.},
  author={Lisa Mosconi and Daniela Perani and Sandro Sorbi and Karl Herholz and Benedetta Nacmias and Vjera A. Holthoff and Erik Salmon and Jean-Claude Baron and Maria Teresa Rosaria De Cristofaro and Alessandro Padovani and Barbara Borroni and M. P. Franceschi and Laura Bracco and Alberto Pupi},
  journal={Neurology},
  year={2004},
  volume={63 12},
  pages={2332-40}
}
OBJECTIVES To investigate whether the combination of fluoro-2-deoxy-d-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHOD After 1 year, 8 of 37 patients with MCI converted to AD (22%). Differences in baseline regional glucose metabolic rate (rCMRglc) across groups were assessed on a voxel-based basis using a two-factor analysis of variance with outcome (converters [n = 8] vs… CONTINUE READING
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