MCF-7 breast carcinoma cells do not express caspase-3

  title={MCF-7 breast carcinoma cells do not express caspase-3},
  author={Reiner U. J{\"a}nicke},
  journal={Breast Cancer Research and Treatment},
Apoptosis, a fundamental process essential for normal tissue homeostasis and development, is closely associated with the activation of a class of aspartate-specific cysteinedependent proteases, called caspases, that lead to the demise of the cell via limited proteolysis of a multitude of cellular substrates [1, 2]. Caspases are expressed as inactive zymogens that become activated upon cleavage by other caspases in a so-called caspase activation cascade, or by mere oligomerization instigated by… CONTINUE READING


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