MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R☆

@article{North1999MCF7BC,
  title={MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R☆},
  author={W. North and M. Fay and Jinlin Du},
  journal={Peptides},
  year={1999},
  volume={20},
  pages={837-842}
}
We have previously provided evidence that an autocrine loop involving vasopressin is present in perhaps all breast cancers. This study now shows MCF-7 breast cancer cells express mRNAs for all currently recognized vasopressin receptor subtypes (V1a, V1b, and V2). Cloning and DNA sequencing over the entire open reading frame of each mRNA revealed that normal sequences representing each receptor were present. However, in addition, an abnormal mRNA for the V2 receptor, expected to give rise to a… Expand
Gene regulation of vasopressin and vasopressin receptors in cancer
  • W. North
  • Biology, Medicine
  • Experimental physiology
  • 2000
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