Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950
- Biology, MedicinePharmacological Reviews
A review of the pharmacology of MCC950 is timely and significant because several next-generation NLRP3 inhibitors are entering proof-of-concept clinical trials in 2020, and its pharmacokinetic and toxicokinetic properties limited its therapeutic development in the clinic.
Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats
- BiologyBioscience reports
The findings indicated that the improvement effect of Dex on TBI was related to its effect on NLRP3 activity, which was associated with the increased neurone viability and suppressed microglia activity.
Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases
- Medicine, BiologyFront. Mol. Neurosci.
The roles of the NLRP3 inflammasome in the pathogenesis and progression of several well-known CNS diseases would be discussed, including cerebrovascular diseases, neurodegenerative diseases, multiple sclerosis, depression as well as other CNS disorders.
SHOWING 1-10 OF 57 REFERENCES
The NLRP3 Inflammasome: A Possible Therapeutic Target for Treatment of Stroke
- Biology, Medicine
The prominent contribution and regulation of NLRP3-inflammasome activation in the pathophysiology of ischemic stroke and recent developments on the potential ofNLRP3 inhibitors in the therapeutic management of stroke outcomes are discussed.
Inflammation in Human Brain Injury: Intracerebral Concentrations of IL-1α, IL-1β, and Their Endogenous Inhibitor IL-1ra
- Biology, Medicine
Feelings of feasibility of the microdialysis methodology in recovering IL-1 family cytokines for assessing their inter-relationships in the injured human brain are demonstrated, and a neuroprotective role forIL-1ra is suggested.
Effect of Erythropoietin and Transfusion Threshold on Neurological Recovery After Traumatic Brain Injury: A Randomized Clinical Trial
Prolonged Activation of NF-?B Following Traumatic Brain Injury in Rats
The results suggest that a neuronal response to brain trauma includes the activation of NF-κB first in the cytoplasm and nucleus of neurons, and this activation persisted for at least 1 year following injury in the cortex.
Cortical expression of nuclear factor κB after human brain contusion
- BiologyBrain Research
Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+ Efflux
- Biology, MedicineThe Journal of Immunology
An essential role for neutrophil-derived IL-1β in S. pneumoniae infection is demonstrated and the role of the NLRP3 inflammasome in cleavage and secretion of IL- 1β in neutrophils is elucidated, which will have implications for other microbial diseases.
Emergency Department Evaluation of Traumatic Brain Injury in the United States, 2009–2010
- MedicineThe Journal of head trauma rehabilitation
The ED is the main gateway to medical care for millions of patients evaluated for TBI each year, and novel diagnostic tests are needed to improve ED diagnosis and management of TBI.
Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury
- Biology, MedicineExperimental Neurology
Induction of thioredoxin-interacting protein is mediated by oxidative stress, calcium, and glucose after brain injury in mice
- BiologyNeurobiology of Disease