MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.

@article{Sasaki2003MCC134AS,
  title={MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.},
  author={Norihito Sasaki and Mitsushige Murata and Yiru Guo and Su-Hyun Jo and Andreas Ohler and Masaharu Akao and Brian O'Rourke and Rui-ping Xiao and Roberto Bolli and Eduardo Marb{\'a}n},
  journal={Circulation},
  year={2003},
  volume={107 8},
  pages={1183-8}
}
BACKGROUND MCC-134 (1-[4-(H-imidazol-1-yl)benzoyl]-N-methylcyclobutane-carbothioamide), a newly developed analog of aprikalim, opens surface smooth muscle-type ATP-sensitive potassium (K(ATP)) channels but inhibits pancreatic K(ATP) channels. However, the effects of MCC-134 on cardiac surface K(ATP) channels and mitochondrial K(ATP) (mitoK(ATP)) channels are unknown. A mixed agonist/blocker with differential effects on the two channel types would help to clarify the role of K(ATP) channels in… CONTINUE READING

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