MCAM-expressing CD4(+) T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune diseases.

@article{Dagur2011MCAMexpressingCT,
  title={MCAM-expressing CD4(+) T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune diseases.},
  author={Pradeep Dagur and Ang{\'e}lique Biancotto and Lai Wei and H. Nida Sen and Michael A Yao and Warren Strober and Robert B. Nussenblatt and J. Philip McCoy},
  journal={Journal of autoimmunity},
  year={2011},
  volume={37 4},
  pages={319-27}
}
Th17 cells are a subset of CD4(+) T cells characterized by production of IL-17 and are known to be key participants in inflammatory reactions and various autoimmune diseases. In this study we found that a subset of human CD4(+) T cells expressing MCAM (CD146) have higher mRNA levels of RORC2, IL-23R, IL-26, IL-22, IL-17A, but not IFN-γ, compared to CD4(+) T cell not expressing CD146. Upon TCR stimulation with CD3/CD28, CD4(+)CD146(+) T cells secrete significantly more IL-17A, IL-6, and IL-8… CONTINUE READING